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The first step in caffeine CYP1A2 metabolism is 3demethylation, which results in 1,7dimethylxanthine (paraxanthine), which accounts for approximately 84% of the major caffeine metabolites

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doi: 10.3389/fimmu.2021.661202 Received 30 January 2021 Accepted 23 August 2021 Published 07 September 2021 Volume 12 - 2021 Edited by Chack-Yung Yu, The Ohio State University, United States Reviewed by Taruna Madan, National Institute for Research in Reproductive Health (ICMR), India

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